Pub. Date : 2003 May-Jun
PMID : 12737942
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. | trichostatin A | hemoglobin subunit gamma 1 | Homo sapiens |
| 2 | Somatic cell hybrids that have undergone globin gene switching and developmental silencing of gamma globin expression were treated with the histone deacetylase inhibitor trichostatin A (TSA). | trichostatin A | hemoglobin subunit gamma 1 | Homo sapiens |
| 3 | Culture of the post-switch hybrids in the presence of TSA reactivated gamma globin expression and concommitantly downregulated beta globin expression, as determined by both mRNA quantitation and immunofluorescent quantitation of gamma globin expressing cells. | trichostatin A | hemoglobin subunit gamma 1 | Homo sapiens |
| 4 | Culture of the post-switch hybrids in the presence of TSA reactivated gamma globin expression and concommitantly downregulated beta globin expression, as determined by both mRNA quantitation and immunofluorescent quantitation of gamma globin expressing cells. | trichostatin A | hemoglobin subunit gamma 1 | Homo sapiens |