Pub. Date : 2003 Jun 27
PMID : 12697749
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. | Cisplatin | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | Here we demonstrate that constitutively active AKT2 renders cisplatin-sensitive A2780S ovarian cancer cells resistant to cisplatin, whereas phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 sensitizes A2780S and cisplatin-resistant A2780CP cells to cisplatin-induced apoptosis through regulation of the ASK1/JNK/p38 pathway. | Cisplatin | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | AKT2 interacts with and phosphorylates ASK1 at Ser-83 resulting in inhibition of its kinase activity. | Serine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | Expression of nonphosphorylatable ASK1-S83A overrode the AKT2-inhibited JNK/p38 activity and Bax conformational changes, whereas phosphomimic ASK1-S83D inhibited the effects of cisplatin on JNK/p38 and Bax. | Cisplatin | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | In conclusion, our data indicate that AKT2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. | Cisplatin | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |