Title : Anti-apoptotic role of phospholipase D isozymes in the glutamate-induced cell death.

Pub. Date : 2003 Feb 28

PMID : 12642902






4 Functional Relationships(s)
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1 The data presented here show that both PLD isozymes, PLD1 and PLD2 are also required in attenuating glutamate-induced cell death in PC12 cells. Glutamic Acid phospholipase D1 Rattus norvegicus
2 When cDNAs of PLD1 and PLD2 were transfected into PC12 cells respectively, overexpression of PLD1 or PLD2 resulted in inhibition of glutamate-induced apoptotic cell death. Glutamic Acid phospholipase D1 Rattus norvegicus
3 When cDNAs of PLD1 and PLD2 were transfected into PC12 cells respectively, overexpression of PLD1 or PLD2 resulted in inhibition of glutamate-induced apoptotic cell death. Glutamic Acid phospholipase D1 Rattus norvegicus
4 These data indicate that both PLD1 and PLD2 play a protective role against glutamate-induced cell death in PC12 cells. Glutamic Acid phospholipase D1 Rattus norvegicus