Title : Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA.

Pub. Date : 2003 Mar

PMID : 12629525






3 Functional Relationships(s)
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1 Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA. 2-(phosphonomethyl)pentanedioic acid folate hydrolase 1 Mus musculus
2 Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA. 2-(phosphonomethyl)pentanedioic acid folate hydrolase 1 Mus musculus
3 The aim of this study was to investigate effects of GCP II inhibition with the selective inhibitor, 2-PMPA, on: (a) development of tolerance to the antinociceptive effects, (b) withdrawal, and (c) conditioned reward produced by morphine in C57/Bl mice. 2-(phosphonomethyl)pentanedioic acid folate hydrolase 1 Mus musculus