Title : Inhibition of apical Na+/H+ exchangers on the macula densa cells augments tubuloglomerular feedback.

Pub. Date : 2003 Mar

PMID : 12623980






3 Functional Relationships(s)
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1 Increasing luminal NaCl concentration increases nNOS activity, NO production, and apical Na+/H+ exchange. Sodium Chloride nitric oxide synthase, brain Oryctolagus cuniculus
2 We hypothesized that inhibiting apical Na+/H+ exchange in macula densa cells would augment TGF by blunting nNOS activation caused by increasing luminal NaCl concentration. Sodium Chloride nitric oxide synthase, brain Oryctolagus cuniculus
3 Thus, it is possible that increased apical Na+/H+ exchange caused by increasing the sodium concentration in the lumen of the macula densa activates macula densa nNOS. Sodium nitric oxide synthase, brain Oryctolagus cuniculus