Pub. Date : 2002 Jun 28
PMID : 12575297
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To explore the interaction of low-dosage aspirin combined with angiotensin-converting enzyme (ACE) inhibitors by prostacyclin (PGI2), thromboxone A2 (TXA2) and norepinephrine (NE)) levels in rabbits" blood. | Epoprostenol | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 2 | OBJECTIVE: To explore the interaction of low-dosage aspirin combined with angiotensin-converting enzyme (ACE) inhibitors by prostacyclin (PGI2), thromboxone A2 (TXA2) and norepinephrine (NE)) levels in rabbits" blood. | Epoprostenol | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 3 | OBJECTIVE: To explore the interaction of low-dosage aspirin combined with angiotensin-converting enzyme (ACE) inhibitors by prostacyclin (PGI2), thromboxone A2 (TXA2) and norepinephrine (NE)) levels in rabbits" blood. | Epoprostenol | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 4 | OBJECTIVE: To explore the interaction of low-dosage aspirin combined with angiotensin-converting enzyme (ACE) inhibitors by prostacyclin (PGI2), thromboxone A2 (TXA2) and norepinephrine (NE)) levels in rabbits" blood. | Epoprostenol | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 5 | OBJECTIVE: To explore the interaction of low-dosage aspirin combined with angiotensin-converting enzyme (ACE) inhibitors by prostacyclin (PGI2), thromboxone A2 (TXA2) and norepinephrine (NE)) levels in rabbits" blood. | Norepinephrine | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 6 | RESULTS: ACE inhibitors increased PGI2 levels (P < 0.05, P < 0.01); low-dosage aspirin suppressed TXA2 productions (P < 0.05, P < 0.01) after the four-week administration. | Epoprostenol | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 7 | Aspirin combined with ACE inhibitors led to a significant increase in PGI2/TXA2(P < 0.01), together with a significant decrease in NE levels in the rabbits" blood (P < 0.001). | Epoprostenol | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 8 | The ratio of PGI2 to TXA2 increased, and NE levels decreased significantly during the administration of aspirin combined with ACE inhibitors. | Epoprostenol | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 9 | The results suggest that there is a synergis-action between low-dosage aspirin and ACE inhibitors due to increased PGI2/TXA2 and decreased NE levels. | Epoprostenol | angiotensin-converting enzyme | Oryctolagus cuniculus |