Title : Cytokine-induced neutrophil chemoattractant 1 (CINC-1) mediates the sympathetic component of inflammatory mechanical hypersensitivitiy in rats.

Pub. Date : 2002 Oct-Dec

PMID : 12517731






3 Functional Relationships(s)
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1 Carrageenin- and TNF-alpha-evoked hypersensitivity were attenuated to about the same extent (50%) by antisera neutralising CINC-1 or IL-1beta. Carrageenan C-X-C motif chemokine ligand 1 Rattus norvegicus
2 In addition, carrageenin, LPS and TNF-alpha were shown to stimulate the production of immunoreactive CINC-1 in the skin of injected paws. Carrageenan C-X-C motif chemokine ligand 1 Rattus norvegicus
3 These data suggest that CINC-1, released at sites of inflammation, mediates inflammatory hyperalgesia in rats via release of sympathomimetic amines. Amines C-X-C motif chemokine ligand 1 Rattus norvegicus