Title : Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium.

Pub. Date : 2003 Feb

PMID : 12421748






3 Functional Relationships(s)
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1 Taurochenodeoxycholate and tauroursodeoxycholate increased forskolin-induced cAMP accumulation to a similar extent, without affecting cAMP basal levels. Taurochenodeoxycholic Acid cathelicidin antimicrobial peptide Homo sapiens
2 This potentiating effect was abrogated after PKC inhibition, whereas both taurochenodeoxycholate and tauroursodeoxycholate induced PKC-alpha and -delta translocation to cell membranes. Taurochenodeoxycholic Acid protein kinase C alpha Homo sapiens
3 cAMP-dependent chloride secretion induced by isoproterenol, a beta-adrenergic agonist, was significantly increased by taurochenodeoxycholate and by tauroursodeoxycholate. Taurochenodeoxycholic Acid cathelicidin antimicrobial peptide Homo sapiens