Title : Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.

Pub. Date : 2002 Oct 29

PMID : 12391316






1 Functional Relationships(s)
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1 Previous work demonstrated that dipeptides with destabilizing N-terminal residues allosterically activate UBR1, leading to accelerated in vivo degradation of CUP9 and the induction of PTR2 expression. Dipeptides Ptr2p Saccharomyces cerevisiae S288C