Title : Properties of extended-spectrum beta-lactamases constructed by site-directed mutagenesis.

Pub. Date : 2002 Sep

PMID : 12373483






5 Functional Relationships(s)
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1 In vitro antibacterial activities of 23 beta-lactam antibiotics were tested against the ESBL producers by the agar dilution method, and the results were compared. beta-Lactams EsbL Escherichia coli
2 The minimum inhibitory concentrations (MICs) of penicillins tested were more than 32 micro g/ml against both the parental RTEM and ESBL producers, but they were substantially decreased by a combination with beta-lactamase inhibitors. Penicillins EsbL Escherichia coli
3 Compared with the MICs against the ESBL-nonproducing host strain, the MICs of the cephalosporins tested for the ESBL producers were increased more than eight times in most cases and in several cases soared to more than 2048 times against a Toho-1 ESBL producer. Cephalosporins EsbL Escherichia coli
4 Compared with the MICs against the ESBL-nonproducing host strain, the MICs of the cephalosporins tested for the ESBL producers were increased more than eight times in most cases and in several cases soared to more than 2048 times against a Toho-1 ESBL producer. Cephalosporins EsbL Escherichia coli
5 Compared with the MICs against the ESBL-nonproducing host strain, the MICs of the cephalosporins tested for the ESBL producers were increased more than eight times in most cases and in several cases soared to more than 2048 times against a Toho-1 ESBL producer. Cephalosporins EsbL Escherichia coli