Pub. Date : 2002 Dec
PMID : 12368230
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aspirin (ASA) regulates 5-lipoxygenase activity and peroxisome proliferator-activated receptor alpha-mediated CINC-1 release in rat liver cells: novel actions of lipoxin A4 (LXA4) and ASA-triggered 15-epi-LXA4. | Aspirin | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 2 | Aspirin (ASA) regulates 5-lipoxygenase activity and peroxisome proliferator-activated receptor alpha-mediated CINC-1 release in rat liver cells: novel actions of lipoxin A4 (LXA4) and ASA-triggered 15-epi-LXA4. | Aspirin | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 3 | In the current investigation, we examined the effects of ASA on COX and 5-lipoxygenase (5-LO) pathways and its impact on peroxisome proliferator-activated receptor alpha (PPARalpha) and cytokine-induced neutrophil chemoattractant-1 (CINC-1) levels in rat liver cells. | Aspirin | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 4 | In hepatocytes, ASA significantly inhibited PPARalpha protein expression and CINC-1 secretion, effects that were also observed in hepatocytes exposed to the selective PPARalpha agonist Wy-14643. | Aspirin | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 5 | In hepatocytes, ASA significantly inhibited PPARalpha protein expression and CINC-1 secretion, effects that were also observed in hepatocytes exposed to the selective PPARalpha agonist Wy-14643. | pirinixic acid | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 6 | In contrast, treatment of hepatocytes with PGE2 in association with LTB4 had no significant effect on PPARalpha but stimulated CINC-1 release. | Dinoprostone | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 7 | Interestingly, the endogenous antiinflammatory eicosanoids LXA4 and ASA-triggered 15-epi-LXA4, in addition to inhibiting macrophage 5-LO activity to a similar extent as PGE2, significantly reduced PPARalpha and CINC-1 levels in hepatocytes. | Eicosanoids | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 8 | Interestingly, the endogenous antiinflammatory eicosanoids LXA4 and ASA-triggered 15-epi-LXA4, in addition to inhibiting macrophage 5-LO activity to a similar extent as PGE2, significantly reduced PPARalpha and CINC-1 levels in hepatocytes. | lipoxin A4 | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 9 | Interestingly, the endogenous antiinflammatory eicosanoids LXA4 and ASA-triggered 15-epi-LXA4, in addition to inhibiting macrophage 5-LO activity to a similar extent as PGE2, significantly reduced PPARalpha and CINC-1 levels in hepatocytes. | Aspirin | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 10 | Interestingly, the endogenous antiinflammatory eicosanoids LXA4 and ASA-triggered 15-epi-LXA4, in addition to inhibiting macrophage 5-LO activity to a similar extent as PGE2, significantly reduced PPARalpha and CINC-1 levels in hepatocytes. | lipoxin A4 | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 11 | Taken together and because arachidonic acid-derived products, PPARalpha levels, and CINC-1 secretion are involved in the extent and duration of an inflammatory response, these findings provide additional molecular mechanisms for the pharmacological properties of ASA. | Aspirin | C-X-C motif chemokine ligand 1 | Rattus norvegicus |