Title : The Ff gene 5 single-stranded DNA-binding protein binds to the transiently folded form of an intramolecular G-quadruplex.

Pub. Date : 2002 Sep 24

PMID : 12234186






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In 200 mM NaCl at 37 degrees C, g5p binds to I-3 in two stages, the first stage being the formation of a discrete intermediate complex that appears to be a precursor to a saturated g5p x I-3 complex. Sodium Chloride G-patch domain and ankyrin repeats 1 Homo sapiens
2 Results were the following: (1) The g5p binds in one stage to I-3c26 in 200 mM NaCl at 37 degrees C. (2) The intermediate complex of g5p.I-3 is formed by the binding of g5p to the core sequence. Sodium Chloride G-patch domain and ankyrin repeats 1 Homo sapiens
3 Results were the following: (1) The g5p binds in one stage to I-3c26 in 200 mM NaCl at 37 degrees C. (2) The intermediate complex of g5p.I-3 is formed by the binding of g5p to the core sequence. Sodium Chloride G-patch domain and ankyrin repeats 1 Homo sapiens
4 Results were the following: (1) The g5p binds in one stage to I-3c26 in 200 mM NaCl at 37 degrees C. (2) The intermediate complex of g5p.I-3 is formed by the binding of g5p to the core sequence. Sodium Chloride G-patch domain and ankyrin repeats 1 Homo sapiens
5 (5) DMS methylation protection and interference experiments identified two guanines that are differentially involved in the steady-state folded and g5p-bound G-quadruplex structures. Guanine G-patch domain and ankyrin repeats 1 Homo sapiens