Title : Gender influence on the dose-ranging of a low-dose perindopril-indapamide combination in hypertension: effect on systolic and pulse pressure.

Pub. Date : 2002 Aug

PMID : 12172328






5 Functional Relationships(s)
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Protein Name
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1 A low-dose combination of perindopril (Per) and indapamide (Ind) has been shown to reduce more SBP than atenolol for the same DBP reduction. Indapamide selenium binding protein 1 Homo sapiens
2 A low-dose combination of perindopril (Per) and indapamide (Ind) has been shown to reduce more SBP than atenolol for the same DBP reduction. Indapamide selenium binding protein 1 Homo sapiens
3 RESULTS: In the overall population, there was a significant dose-response relationship (P < 0.001) for doubling the dose of Per 2/Ind 0.625 mg up to Per 8/Ind 2.5 mg with a progressive fall in SBP, DBP, MBP. Indapamide period circadian regulator 2 Homo sapiens
4 RESULTS: In the overall population, there was a significant dose-response relationship (P < 0.001) for doubling the dose of Per 2/Ind 0.625 mg up to Per 8/Ind 2.5 mg with a progressive fall in SBP, DBP, MBP. Indapamide period circadian regulator 2 Homo sapiens
5 CONCLUSION: In hypertensive subjects, the low-dose combinations Per 2/Ind 0.625 and Per 4/Ind 1.25 are the most effective in reducing blood pressure and avoiding hypokalemia. Indapamide period circadian regulator 2 Homo sapiens