Title : Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene.

Pub. Date : 2002 Oct 11

PMID : 12169689






3 Functional Relationships(s)
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1 Pretreatment of HT1080-derived fibrosarcoma cells with pharmacological inhibitors of PI3K (wortmannin or LY294002) selectively inhibited IFN-beta-induced beta-R1 mRNA accumulation in a dose-dependent manner. Wortmannin interferon beta-1 Bos taurus
2 Pretreatment of HT1080-derived fibrosarcoma cells with pharmacological inhibitors of PI3K (wortmannin or LY294002) selectively inhibited IFN-beta-induced beta-R1 mRNA accumulation in a dose-dependent manner. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one interferon beta-1 Bos taurus
3 Furthermore, IFN-beta-mediated phosphorylation of GST-p65 was blocked by pretreatment with LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one interferon beta-1 Bos taurus