Pub. Date : 2002 Aug
PMID : 12130674
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | zfAHR2 can dimerize with zfARNT2b and binds with specificity to dioxin-responsive elements (DREs). | Dioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 2 | In COS-7 cells expressing zfARNT2b and zfAHR2, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure leads to a significant induction of dioxin-responsive reporter genes. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 3 | In COS-7 cells expressing zfARNT2b and zfAHR2, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure leads to a significant induction of dioxin-responsive reporter genes. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 4 | In COS-7 cells expressing zfARNT2b and zfAHR2, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure leads to a significant induction of dioxin-responsive reporter genes. | Dioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 5 | Ligand-binding experiments suggested that the differential zfAHR activities are attributable to differences in TCDD binding because only zfAHR2 exhibits high-affinity binding to [(3)H]TCDD or beta-naphthoflavone. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 6 | Ligand-binding experiments suggested that the differential zfAHR activities are attributable to differences in TCDD binding because only zfAHR2 exhibits high-affinity binding to [(3)H]TCDD or beta-naphthoflavone. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 7 | Ligand-binding experiments suggested that the differential zfAHR activities are attributable to differences in TCDD binding because only zfAHR2 exhibits high-affinity binding to [(3)H]TCDD or beta-naphthoflavone. | beta-Naphthoflavone | aryl hydrocarbon receptor 2 | Danio rerio |
| 8 | Finally, using chimeric zfAHR1/zfAHR2 constructs, the lack of TCDD-mediated transcriptional activity was localized to the ligand-binding and C-terminal domains of zfAHR1. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |