Title : Optimisation of carbomer viscous eye drops: an in vitro experimental design approach using rheological techniques.

Pub. Date : 2002 Jul

PMID : 12084501






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1 The optimisation of the in vitro interaction between several poly(acrylic acid) derivatives (Carbopol 1342P NF, Carbopol 974P and Carbopol 980 NF) and mucin was performed by an analysis technique combining oscillatory shear rheology and experimental design in order to improve the formulation of carbomer viscous eye drops.First, standard oscillation procedures were used to characterise the polyacrylic acid and mucin dispersions, and to investigate the influence of several polymer-related factors (concentration, preparation, type of polymer used) on the rheological properties. carbopol 940 LOC100508689 Homo sapiens