Title : Homologous recombinational repair vis-à-vis chlorambucil resistance in chronic lymphocytic leukemia.

Pub. Date : 2002 May 1

PMID : 12007561






3 Functional Relationships(s)
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1 In this report, we measured the protein levels of HsRad51 and Xrcc3 (an HsRad51 paralog) and correlated them with the in vitro CLB cytotoxicity (LD(50)) in lymphocytes from seventeen B-CLL patients. Chlorambucil X-ray repair cross complementing 3 Homo sapiens
2 Both HsRad51 (r=0.75, P=0.0005) and Xrcc3 (r=0.52, P=0.03) protein levels correlated with the in vitro CLB LD(50). Chlorambucil X-ray repair cross complementing 3 Homo sapiens
3 Our data suggest that HsRad51 and Xrcc3 protein expression may be predictive of the response in B-CLL patients to treatment with nitrogen mustards. Nitrogen X-ray repair cross complementing 3 Homo sapiens