Pub. Date : 2002 May
PMID : 11994980
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 2 | all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 3 | We found that treatment of NB4 cells with a pharmacological concentration of ATRA (1 microM) induced rapid and dose-dependent expression of CYP26 mRNA. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 4 | The CYP26 expression returned to pretreatment levels in both cells after ATRA was removed from the media. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 5 | Retinoic acid receptor-alpha (RARalpha) specific antagonist (CD2503) totally abolished the ATRA-induced expression of CYP26 mRNA in HL-60 and NB4 cells. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 6 | ATRA-induced expression of CYP26 was restored in HL-60R cells retrovirally transduced with RARalpha, but not in those cells transduced with the other retinoid receptors. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 7 | In conclusion, ATRA induces expression of CYP26 in myeloid and promyelocytic leukemia cells and this expression is modulated by RARalpha. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 8 | The induction of CYP26 expression by ATRA treatment might be related to a substrate-driven feedback mechanism to regulate intracellular concentrations of ATRA and its over expression in some clones may be partly responsible for reduced sensitivity or resistance to ATRA therapy. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 9 | The induction of CYP26 expression by ATRA treatment might be related to a substrate-driven feedback mechanism to regulate intracellular concentrations of ATRA and its over expression in some clones may be partly responsible for reduced sensitivity or resistance to ATRA therapy. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 10 | The induction of CYP26 expression by ATRA treatment might be related to a substrate-driven feedback mechanism to regulate intracellular concentrations of ATRA and its over expression in some clones may be partly responsible for reduced sensitivity or resistance to ATRA therapy. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |