Title : Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury.

Pub. Date : 2002 Apr

PMID : 11966529






2 Functional Relationships(s)
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1 Similarly, the selective COX-1 inhibitor SC-560 also caused no gastric damage, despite inhibiting PGE2 production. SC 560 cytochrome c oxidase I, mitochondrial Rattus norvegicus
2 The normal gastric mucosa expressed COX-1 mRNA and not COX-2 mRNA, but COX-2 mRNA was expressed in the stomach after administration of SC-560 as well as indomethacin but not rofecoxib. SC 560 cytochrome c oxidase II, mitochondrial Rattus norvegicus