Title : Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors.

Pub. Date : 2002 Jan

PMID : 11792566






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Nitrogen-containing bisphosphonates (NBps) are taken up by osteoclasts and inhibit farnesyl pyrophosphate synthase, an enzyme of the mevalonate pathway. Nitrogen farnesyl diphosphate synthetase Mus musculus
2 Nitrogen-containing bisphosphonates (NBps) are taken up by osteoclasts and inhibit farnesyl pyrophosphate synthase, an enzyme of the mevalonate pathway. Diphosphonates farnesyl diphosphate synthetase Mus musculus
3 Nitrogen-containing bisphosphonates (NBps) are taken up by osteoclasts and inhibit farnesyl pyrophosphate synthase, an enzyme of the mevalonate pathway. Mevalonic Acid farnesyl diphosphate synthetase Mus musculus