Title : Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages.

Pub. Date : 2002 Jan

PMID : 11789661






2 Functional Relationships(s)
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1 Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages. Dibenzylbutyrolactone v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
2 RESULTS: Arctigenin (1 microM) inhibited lipopolysaccharide (LPS)-inducible nuclear NF-kappaB activation and nuclear translocation of p65, which was accompanied by inhibition of I-kappaBalpha phosphorylation, whereas demethyltraxillagenin was less active. arctigenin v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus