Title : Effects of lipoproteins on cyclosporine A toxicity and uptake in LLC-PK1 pig kidney cells.

Pub. Date : 2001 Sep

PMID : 11745792






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ApoA-I, the major protein component of HDL, and intact LDL particles showed the most significant effects of CSA uptake and toxicity. Cyclosporine apolipoprotein A1 Sus scrofa
2 The uptake and toxicity of CSA was effectively reduced with elevated LDL concentrations but showed a significant increase (p < 0.05) when incubated with elevated concentrations of apoA-I. Cyclosporine apolipoprotein A1 Sus scrofa
3 LDL and apoA-I are identified as the major effectors of CSA toxicity and uptake in LLC-PK(1) cells. Cyclosporine apolipoprotein A1 Sus scrofa