Title : Fatty acids enhance GRO/CINC-1 and interleukin-6 production in rat intestinal epithelial cells.

Pub. Date : 2001 Nov

PMID : 11694623






10 Functional Relationships(s)
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1 Fatty acids enhance GRO/CINC-1 and interleukin-6 production in rat intestinal epithelial cells. Fatty Acids C-X-C motif chemokine ligand 1 Rattus norvegicus
2 Fatty acids enhance GRO/CINC-1 and interleukin-6 production in rat intestinal epithelial cells. Fatty Acids C-X-C motif chemokine ligand 1 Rattus norvegicus
3 In this study, we examined how exposure to fatty acids affects the production of growth-regulated oncogene/cytokine-induced neutrophil chemoattractant-1 (GRO/CINC-1) and interleukin (IL)-6 in rat intestinal epithelial cells (IEC). Fatty Acids C-X-C motif chemokine ligand 1 Rattus norvegicus
4 In this study, we examined how exposure to fatty acids affects the production of growth-regulated oncogene/cytokine-induced neutrophil chemoattractant-1 (GRO/CINC-1) and interleukin (IL)-6 in rat intestinal epithelial cells (IEC). Fatty Acids C-X-C motif chemokine ligand 1 Rattus norvegicus
5 Administration of long-chain fatty acids significantly increased the GRO/CINC-1 and IL-6 secretion into culture media, and this secretion was markedly increased (P < 0.05) in the presence of IL-1beta or TGF-beta. long-chain fatty acids C-X-C motif chemokine ligand 1 Rattus norvegicus
6 Administration of long-chain fatty acids significantly increased the GRO/CINC-1 and IL-6 secretion into culture media, and this secretion was markedly increased (P < 0.05) in the presence of IL-1beta or TGF-beta. long-chain fatty acids C-X-C motif chemokine ligand 1 Rattus norvegicus
7 Furthermore, treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and IL-6 expression that was induced by IL-1beta or TGF-beta. long-chain fatty acids C-X-C motif chemokine ligand 1 Rattus norvegicus
8 Furthermore, treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and IL-6 expression that was induced by IL-1beta or TGF-beta. long-chain fatty acids C-X-C motif chemokine ligand 1 Rattus norvegicus
9 Inhibitors of phospholipase C, protein kinase C or MAPK significantly reduced the fatty acid-induced increase in GRO/CINC-1 secretion, whereas a calcium/calmodulin inhibitor did not attenuate the secretion. Fatty Acids C-X-C motif chemokine ligand 1 Rattus norvegicus
10 Inhibitors of phospholipase C, protein kinase C or MAPK significantly reduced the fatty acid-induced increase in GRO/CINC-1 secretion, whereas a calcium/calmodulin inhibitor did not attenuate the secretion. Fatty Acids C-X-C motif chemokine ligand 1 Rattus norvegicus