Title : Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

Pub. Date : 2001 Dec 21

PMID : 11581260






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Nitrogen-containing bisphosphonate drugs inhibit bone resorption by inhibiting FPP synthase and thereby preventing the synthesis of isoprenoid lipids required for protein prenylation in bone-resorbing osteoclasts. Nitrogen farnesyl diphosphate synthetase Mus musculus
2 Nitrogen-containing bisphosphonate drugs inhibit bone resorption by inhibiting FPP synthase and thereby preventing the synthesis of isoprenoid lipids required for protein prenylation in bone-resorbing osteoclasts. Diphosphonates farnesyl diphosphate synthetase Mus musculus