Title : Determinants of agonist binding affinity on neuronal nicotinic receptor beta subunits.

Pub. Date : 2001 Oct

PMID : 11561103






1 Functional Relationships(s)
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1 Using saturation and competition analysis of receptors formed by chimeric beta subunits coexpressed with alpha2 in Xenopus laevis oocytes, we have now identified sequence segment 54-63 (corresponding to loop D) as a major determinant of affinity for epibatidine, ACh, nicotine, and DMPP. epibatidine MGC75582, possible similarity to act2 S homeolog Xenopus laevis