Title : Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity.

Pub. Date : 2001 Sep 14

PMID : 11556844






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The MDD2 cell line was significantly more resistant to the cytotoxic effects of vinblastine and paclitaxel than the MN1 cell line. Vinblastine MDD2 Homo sapiens
2 The MDD2 cell line was significantly more resistant to the cytotoxic effects of vinblastine and paclitaxel than the MN1 cell line. Paclitaxel MDD2 Homo sapiens
3 After exposure to vinblastine, Raf 1 kinase activity was reduced in MDD2 cells but not in MN1 cells. Vinblastine MDD2 Homo sapiens
4 Addition of flavopiridol to vinblastine- and paclitaxel-treated cells reversed the MDD2-resistant phenotype by inducing G(1)cell cycle arrest and inhibiting endoreduplication. alvocidib MDD2 Homo sapiens
5 Addition of flavopiridol to vinblastine- and paclitaxel-treated cells reversed the MDD2-resistant phenotype by inducing G(1)cell cycle arrest and inhibiting endoreduplication. Vinblastine MDD2 Homo sapiens
6 Addition of flavopiridol to vinblastine- and paclitaxel-treated cells reversed the MDD2-resistant phenotype by inducing G(1)cell cycle arrest and inhibiting endoreduplication. Paclitaxel MDD2 Homo sapiens