Pub. Date : 2001 Jul 11
PMID : 11470516
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs. | Quinidine | Tpo1p | Saccharomyces cerevisiae S288C |
| 2 | The drug sensitivity of the strains deleted for these genes revealed that TPO1, a gene previously found to be involved in spermidine resistance and vacuolar polyamine transport, is a determinant of multidrug transporter since it also mediates growth resistance to cycloheximide and quinidine. | Spermidine | Tpo1p | Saccharomyces cerevisiae S288C |
| 3 | The drug sensitivity of the strains deleted for these genes revealed that TPO1, a gene previously found to be involved in spermidine resistance and vacuolar polyamine transport, is a determinant of multidrug transporter since it also mediates growth resistance to cycloheximide and quinidine. | Polyamines | Tpo1p | Saccharomyces cerevisiae S288C |
| 4 | The drug sensitivity of the strains deleted for these genes revealed that TPO1, a gene previously found to be involved in spermidine resistance and vacuolar polyamine transport, is a determinant of multidrug transporter since it also mediates growth resistance to cycloheximide and quinidine. | Cycloheximide | Tpo1p | Saccharomyces cerevisiae S288C |
| 5 | The drug sensitivity of the strains deleted for these genes revealed that TPO1, a gene previously found to be involved in spermidine resistance and vacuolar polyamine transport, is a determinant of multidrug transporter since it also mediates growth resistance to cycloheximide and quinidine. | Quinidine | Tpo1p | Saccharomyces cerevisiae S288C |
| 6 | Both YOR273C and TPO1 as well as at least one other determinant involved in the yeast pleiotropic drug resistance network contribute to resistance to a quinoline-containing antimalarial drug. | quinoline | Tpo1p | Saccharomyces cerevisiae S288C |