Title : Biotin reagents for antibody pretargeting. 5. Additional studies of biotin conjugate design to provide biotinidase stability.

Pub. Date : 2001 Jul-Aug

PMID : 11459467






2 Functional Relationships(s)
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1 An investigation was conducted in which the stabilities of four structurally different biotin derivatives were assessed with regard to biotinamide bond hydrolysis by the enzyme biotinidase. biotinamide biotinidase Homo sapiens
2 The results indicate that increasing the distance from the biotin ring structure to the biotinamide bond by one methylene only decreases the rate of biotinidase cleavage, but does not block it. biotinamide biotinidase Homo sapiens