Title : Differential DNA recognition and glycosylase activity of the native human MutY homolog (hMYH) and recombinant hMYH expressed in bacteria.

Pub. Date : 2001 Jun 15

PMID : 11410677






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human MutY homolog (hMYH), an adenine DNA glycosylase, can effectively remove misincorporated adenines opposite template G or 8-oxoG bases, thereby preventing G:C-->T:A transversions. Adenine mutY DNA glycosylase Homo sapiens
2 Moreover, the protein-DNA complex of bacterially expressed hMYH migrates much faster than that of native hMYH in a non-denaturing polyacrylamide gel. polyacrylamide mutY DNA glycosylase Homo sapiens
3 Moreover, the protein-DNA complex of bacterially expressed hMYH migrates much faster than that of native hMYH in a non-denaturing polyacrylamide gel. polyacrylamide mutY DNA glycosylase Homo sapiens