Title : Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease.

Pub. Date : 2001 Jun 1

PMID : 11406612






1 Functional Relationships(s)
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1 In this study, we show by using a filter retardation assay and immunofluorescence microscopy that treatment of mammalian cells with geldanamycin at nanomolar concentrations induces the expression of Hsp40, Hsp70 and Hsp90 and inhibits HD exon 1 protein aggregation in a dose-dependent manner. geldanamycin DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 Homo sapiens