Pub. Date : 2001 Jul
PMID : 11375762
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-acetylated-a-linked acidic dipeptidase (NAALADase, EC 3.4.17.21) is responsible for the hydrolysis of NAAG into N-acetylaspartate (NAA) and glutamate. | isospaglumic acid | folate hydrolase 1 | Homo sapiens |
| 2 | N-acetylated-a-linked acidic dipeptidase (NAALADase, EC 3.4.17.21) is responsible for the hydrolysis of NAAG into N-acetylaspartate (NAA) and glutamate. | isospaglumic acid | folate hydrolase 1 | Homo sapiens |
| 3 | N-acetylated-a-linked acidic dipeptidase (NAALADase, EC 3.4.17.21) is responsible for the hydrolysis of NAAG into N-acetylaspartate (NAA) and glutamate. | N-acetylaspartate | folate hydrolase 1 | Homo sapiens |
| 4 | N-acetylated-a-linked acidic dipeptidase (NAALADase, EC 3.4.17.21) is responsible for the hydrolysis of NAAG into N-acetylaspartate (NAA) and glutamate. | N-acetylaspartate | folate hydrolase 1 | Homo sapiens |
| 5 | N-acetylated-a-linked acidic dipeptidase (NAALADase, EC 3.4.17.21) is responsible for the hydrolysis of NAAG into N-acetylaspartate (NAA) and glutamate. | N-acetylaspartate | folate hydrolase 1 | Homo sapiens |
| 6 | N-acetylated-a-linked acidic dipeptidase (NAALADase, EC 3.4.17.21) is responsible for the hydrolysis of NAAG into N-acetylaspartate (NAA) and glutamate. | Glutamic Acid | folate hydrolase 1 | Homo sapiens |
| 7 | N-acetylated-a-linked acidic dipeptidase (NAALADase, EC 3.4.17.21) is responsible for the hydrolysis of NAAG into N-acetylaspartate (NAA) and glutamate. | Glutamic Acid | folate hydrolase 1 | Homo sapiens |
| 8 | If NAAG is a storage form of glutamate, then inhibition of NAALADase should be neuroprotective in diseases in which excess glutamatergic transmission is detrimental. | isospaglumic acid | folate hydrolase 1 | Homo sapiens |
| 9 | If NAAG is a storage form of glutamate, then inhibition of NAALADase should be neuroprotective in diseases in which excess glutamatergic transmission is detrimental. | Glutamic Acid | folate hydrolase 1 | Homo sapiens |
| 10 | Therefore, inhibition of NAALADase would also function to increase NAAG levels which, in turn, should provide neuroprotection via the interaction of NAAG with these receptors. | isospaglumic acid | folate hydrolase 1 | Homo sapiens |
| 11 | Therefore, inhibition of NAALADase would also function to increase NAAG levels which, in turn, should provide neuroprotection via the interaction of NAAG with these receptors. | isospaglumic acid | folate hydrolase 1 | Homo sapiens |
| 12 | As such, NAALADase inhibition represents a novel method of regulating extracellular glutamate levels and provides a new avenue for the treatment of neurological disorders. | Glutamic Acid | folate hydrolase 1 | Homo sapiens |