Title : PPARalpha gene expression in the developing rat kidney: role of glucocorticoids.

Pub. Date : 2001 Jun

PMID : 11373342






3 Functional Relationships(s)
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1 Finally, with the use of an established renal cell line, it was shown that glucocorticoids stimulate gene expression of PPARalpha and of medium chain acyl-CoA dehydrogenase (MCAD, a PPARalpha target gene) 2- to 4-fold and 1.5-fold, respectively, and that addition of fatty acids in the culture media led to a 2.2-fold increase in MCAD mRNA. Fatty Acids acyl-CoA dehydrogenase medium chain Rattus norvegicus
2 Finally, with the use of an established renal cell line, it was shown that glucocorticoids stimulate gene expression of PPARalpha and of medium chain acyl-CoA dehydrogenase (MCAD, a PPARalpha target gene) 2- to 4-fold and 1.5-fold, respectively, and that addition of fatty acids in the culture media led to a 2.2-fold increase in MCAD mRNA. Fatty Acids acyl-CoA dehydrogenase medium chain Rattus norvegicus
3 Altogether, these results demonstrated that glucocorticoids are potent regulators of PPARalpha development in the immature kidney and that these hormones act in concert with fatty acids to regulate MCAD gene expression in renal cells. Fatty Acids acyl-CoA dehydrogenase medium chain Rattus norvegicus