Title : Allosteric modulation in spontaneously active mutant gamma-aminobutyric acidA receptors.

Pub. Date : 2001 Jun 1

PMID : 11356312






1 Functional Relationships(s)
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1 Tryptophan substitutions were made in the second transmembrane domain of the gamma-aminobutyric acid(A) (GABAA) receptor alpha and beta subunits and the resulting mutant receptors, containing alpha2(S270W) and/or beta1 (S265W), were expressed in Xenopus oocytes. Tryptophan MGC75582, possible similarity to act2 S homeolog Xenopus laevis