Title : Enhanced turnover of all-trans-retinoic acid and increased formation of polar metabolites in head and neck squamous cell carcinoma lines compared with normal oral keratinocytes.

Pub. Date : 2001 Apr

PMID : 11309353






3 Functional Relationships(s)
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1 Furthermore, the mRNA expression of the RA-specific 4-hydroxylase, CYP26A1, was dramatically increased after RA-induction in the two HNSCC cell lines with the highest metabolism, was undetectable in normal keratinocytes, and was not inducible by RA. Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens
2 Furthermore, the mRNA expression of the RA-specific 4-hydroxylase, CYP26A1, was dramatically increased after RA-induction in the two HNSCC cell lines with the highest metabolism, was undetectable in normal keratinocytes, and was not inducible by RA. Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens
3 Next, introduction of CYP26A1 cDNA in a low-metabolizing HNSCC cell line resulted in an 11-fold higher turnover rate of RA and a 12-fold increase in the amount of polar metabolites, but it did not change sensitivity to RA. Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens