Title : Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity.

Pub. Date : 2001 Apr 27

PMID : 11278295






2 Functional Relationships(s)
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1 By comparison, the RYR3 isoform expressed in HEK-293 cells was significantly inhibited by dantrolene, and the extent of RYR3 inhibition was similar to that displayed by the RYR1 in native SR vesicles. Dantrolene ryanodine receptor 3 Homo sapiens
2 Our results thus indicate that both the RYR1 and the RYR3, but not the RYR2, may be targets for dantrolene inhibition in vivo. Dantrolene ryanodine receptor 3 Homo sapiens