Pub. Date : 2001 Apr
PMID : 11259552
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The cardioprotective efficacy of zoniporide (CP-597,396), a novel, potent, and selective inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE-1), was evaluated both in vitro and in vivo using rabbit models of myocardial ischemia-reperfusion injury. | zoniporide | sodium/hydrogen exchanger 1 | Oryctolagus cuniculus |
| 2 | In open-chest, anesthetized rabbits, zoniporide also elicited a dose-dependent reduction in infarct size (ED(50) of 0.45 mg/kg/h) and inhibited NHE-1-mediated platelet swelling (maximum inhibition 93%). | zoniporide | sodium/hydrogen exchanger 1 | Oryctolagus cuniculus |
| 3 | Zoniporide represents a novel class of potent NHE-1 inhibitors with potential utility for providing clinical cardioprotection. | zoniporide | sodium/hydrogen exchanger 1 | Oryctolagus cuniculus |