Pub. Date : 2001 Mar
PMID : 11258980
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thioredoxin reductase (TR), an NADPH-dependent flavoenzyme that catalyzes the reduction of many disulfide-containing substrates, plays an important role in the cellular response to oxidative stress. | Disulfides | peroxiredoxin 5 | Rattus norvegicus |
| 2 | Thioredoxin reductase (TR), an NADPH-dependent flavoenzyme that catalyzes the reduction of many disulfide-containing substrates, plays an important role in the cellular response to oxidative stress. | Disulfides | peroxiredoxin 5 | Rattus norvegicus |
| 3 | Because MAs(III) is produced in the biomethylation of As, it was postulated that the extent of inhibition of TR in cultured rat hepatocytes would correlate with the intracellular concentration of methyl As. | Arsenic | peroxiredoxin 5 | Rattus norvegicus |
| 4 | Exposure of cultured hepatocytes to inorganic As(III) (iAs(III)), MAs(III), or aurothioglucose (ATG, a competitive inhibitor of TR activity) for 30 min caused a concentration-dependent reduction in TR activity. | Aurothioglucose | peroxiredoxin 5 | Rattus norvegicus |
| 5 | Exposure of cultured hepatocytes to inorganic As(III) (iAs(III)), MAs(III), or aurothioglucose (ATG, a competitive inhibitor of TR activity) for 30 min caused a concentration-dependent reduction in TR activity. | Aurothioglucose | peroxiredoxin 5 | Rattus norvegicus |
| 6 | Exposure of cultured hepatocytes to inorganic As(III) (iAs(III)), MAs(III), or aurothioglucose (ATG, a competitive inhibitor of TR activity) for 30 min caused a concentration-dependent reduction in TR activity. | Aurothioglucose | peroxiredoxin 5 | Rattus norvegicus |
| 7 | After exposure for 3 h [when most MAs(III) has been converted to dimethyl As (DMAs)], TR activity in these cells had returned to control levels. | dimethyl as | peroxiredoxin 5 | Rattus norvegicus |
| 8 | After exposure for 3 h [when most MAs(III) has been converted to dimethyl As (DMAs)], TR activity in these cells had returned to control levels. | Dimethyl acetylsuccinate | peroxiredoxin 5 | Rattus norvegicus |