Pub. Date : 2001 Feb
PMID : 11246672
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To determine the in vitro effects of tetracyclines and nonsteroidal antiiflammatory drugs on interleukin 1alpha (IL-1alpha) induced NO production and biosynthesis of inducible NO synthase (iNOS) by articular chondrocytes. | Tetracyclines | nitric oxide synthase 2 | Bos taurus |
| 2 | RESULTS: Minocycline dose dependently reduced IL-1 stimulated NO production by inhibition of the mRNA expression (IC50 = 69.9 microM) and protein synthesis (IC50 = 37.11 microM) of iNOS. | Minocycline | nitric oxide synthase 2 | Bos taurus |
| 3 | Diclofenac-Na at a concentration of 10 microM only weakly reduced nitrite accumulation and mRNA expression of iNOS. | Diclofenac | nitric oxide synthase 2 | Bos taurus |
| 4 | CONCLUSION: Inhibition of iNOS in articular chondrocytes may be a new mechanism by which minocycline could exert its beneficial effects in the treatment of joint diseases. | Minocycline | nitric oxide synthase 2 | Bos taurus |