Title : Effects of COX-1 and COX-2 inhibitors on eicosanoid biosynthesis and the release of substance P from the guinea-pig isolated perfused lung.

Pub. Date : 2001 Jan

PMID : 11235022






1 Functional Relationships(s)
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1 RESULTS: In non-stimulated preparations, indomethacin (2 microM) and the selective COX-1 inhibitor SC-560 (0.03-1 microM) reduced basal release of 6-keto-PGF1alpha, without significantly affecting the release of cysteinyl-LT and SP. SC 560 cytochrome c oxidase subunit I Cavia porcellus