Pub. Date : 2001 Feb 13
PMID : 11172039
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | sGC activators or cGMP analogs increased expression of the gamma-globin gene in erythroleukemic cells as well as in primary erythroblasts from normal subjects and patients with beta-thalassemia. | Cyclic GMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 2 | Nuclear run-off assays showed that the sGC activator protoporphyrin IX stimulates transcription of the gamma-globin gene. | protoporphyrin IX | hemoglobin subunit gamma 1 | Homo sapiens |
| 3 | Furthermore, increased expression of the gamma-globin gene by well known Hb F-inducers such as hemin and butyrate was abolished by inhibiting sGC or PKG activity. | Hemin | hemoglobin subunit gamma 1 | Homo sapiens |
| 4 | Furthermore, increased expression of the gamma-globin gene by well known Hb F-inducers such as hemin and butyrate was abolished by inhibiting sGC or PKG activity. | Butyrates | hemoglobin subunit gamma 1 | Homo sapiens |