Title : GM-CSF regulates protein and lipid catabolism by alveolar macrophages.

Pub. Date : 2001 Mar

PMID : 11159019






2 Functional Relationships(s)
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1 Metabolism of surfactant protein (SP) A and dipalmitoylphosphatidylcholine (DPPC) was assessed in alveolar macrophages isolated from granulocyte-macrophage colony-stimulated factor (GM-CSF) gene-targeted [GM(-/-)] mice, wild-type mice, and GM(-/-) mice expressing GM-CSF under control of the SP-C promoter element (SP-C-GM). gm surfactant associated protein A1 Mus musculus
2 Although binding and uptake of (125)I-SP-A were significantly increased in alveolar macrophages from GM(-/-) compared with wild type or SP-C-GM mice, catabolism of (125)I-SP-A was markedly decreased in GM(-/-) mice. gm surfactant associated protein A1 Mus musculus