Title : Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.

Pub. Date : 2000 Dec

PMID : 11156248






1 Functional Relationships(s)
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1 Although the taxanes, paclitaxel or docetaxel, as single agents markedly inhibited the growth of A431, LX-1, SK-LC-16, TSU-PR1, and PC-3, when combined with ZD1839, partial or complete regression was usually seen. Docetaxel proprotein convertase subtilisin/kexin type 1 Homo sapiens