Title : Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors.

Pub. Date : 2001 May 4

PMID : 11154698






1 Functional Relationships(s)
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1 We have now determined high resolution (1.8 A) crystal structures for EDN in complex with adenosine-3",5"-diphosphate (3",5"-ADP), adenosine-2",5"-di-phosphate (2",5"-ADP), adenosine-5"-diphosphate (5"-ADP) as well as for a native structure in the presence of sulfate refined at 1.6 A. adenosine 5'-O-(2-thiodiphosphate) ribonuclease A family member 2 Homo sapiens