Pub. Date : 2000 Oct
PMID : 11097380
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytotoxicity of cyclophosphamide, paclitaxel, and docetaxel for tumor cell lines in vitro: effects of concentration, time and cytochrome P450-catalyzed metabolism. | Docetaxel | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. | Docetaxel | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 3 | Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. | Docetaxel | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 4 | Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. | Docetaxel | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 5 | Cytotoxicity of DTX and PCT for P388D1 cells became apparent 24 h after a 2-h incubation period with the drugs, and their effects were enhanced by CYP2E1 microsomes, but markedly decreased by CYP3A-induced microsomes. | Docetaxel | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 6 | Cytotoxicity of DTX and PCT for P388D1 cells became apparent 24 h after a 2-h incubation period with the drugs, and their effects were enhanced by CYP2E1 microsomes, but markedly decreased by CYP3A-induced microsomes. | Docetaxel | cytochrome P450, family 3, subfamily a, polypeptide 11 | Mus musculus |