Pub. Date : 2001 Feb 23
PMID : 11096076
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | Fas ligation activated apoptosis signal-regulating kinase 1 (ASK1) and c-Jun N-terminal kinase (JNK; also known as stress-activated protein kinase (SAPK)) in Gln-deprived cells but not in normal cells, suggesting that Gln might be involved in the activity control of ASK1 and JNK/SAPK. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | Fas ligation activated apoptosis signal-regulating kinase 1 (ASK1) and c-Jun N-terminal kinase (JNK; also known as stress-activated protein kinase (SAPK)) in Gln-deprived cells but not in normal cells, suggesting that Gln might be involved in the activity control of ASK1 and JNK/SAPK. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | Fas ligation activated apoptosis signal-regulating kinase 1 (ASK1) and c-Jun N-terminal kinase (JNK; also known as stress-activated protein kinase (SAPK)) in Gln-deprived cells but not in normal cells, suggesting that Gln might be involved in the activity control of ASK1 and JNK/SAPK. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | As one of the possible mechanisms for the suppressive effect of Gln on ASK1, we investigated the molecular interaction between human glutaminyl-tRNA synthetase (QRS) and ASK1 and found the Gln-dependent association of the two molecules. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 6 | As one of the possible mechanisms for the suppressive effect of Gln on ASK1, we investigated the molecular interaction between human glutaminyl-tRNA synthetase (QRS) and ASK1 and found the Gln-dependent association of the two molecules. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 7 | As one of the possible mechanisms for the suppressive effect of Gln on ASK1, we investigated the molecular interaction between human glutaminyl-tRNA synthetase (QRS) and ASK1 and found the Gln-dependent association of the two molecules. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 8 | As one of the possible mechanisms for the suppressive effect of Gln on ASK1, we investigated the molecular interaction between human glutaminyl-tRNA synthetase (QRS) and ASK1 and found the Gln-dependent association of the two molecules. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 9 | Finally, we have shown that QRS inhibited the cell death induced by ASK1, and this antiapoptotic function of QRS was weakened by the deprivation of Gln. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 10 | Thus, the antiapoptotic interaction of QRS with ASK1 is controlled positively by the cellular concentration of Gln and negatively by Fas ligation. | Glutamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |