Title : Biphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits.

Pub. Date : 2000 Nov

PMID : 11045973






2 Functional Relationships(s)
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1 In conscious rabbits, a sequence of six 4-min coronary occlusion/4-min reperfusion cycles, which elicits late preconditioning (PC), caused rapid activation of calcium-dependent nitric oxide (NO) synthase (NOS) [cNOS; endothelial NOS (eNOS) and/or neuronal NOS (nNOS)], whereas calcium-independent NOS [inducible NOS (iNOS)] activity remained unchanged. Calcium nitric oxide synthase, brain Oryctolagus cuniculus
2 In conscious rabbits, a sequence of six 4-min coronary occlusion/4-min reperfusion cycles, which elicits late preconditioning (PC), caused rapid activation of calcium-dependent nitric oxide (NO) synthase (NOS) [cNOS; endothelial NOS (eNOS) and/or neuronal NOS (nNOS)], whereas calcium-independent NOS [inducible NOS (iNOS)] activity remained unchanged. Calcium nitric oxide synthase, brain Oryctolagus cuniculus