Pub. Date : 2000 Oct 15
PMID : 11032766
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that pretreatment of Cyp2e1(-/-) mice with ethanol plus isopentanol, the predominant alcohols in alcoholic beverages, for 7 days resulted in micro- and macrovesicular steatosis in the livers of all mice, as well as a dramatic increase in acetaminophen hepatotoxicity. | isopentyl alcohol | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 2 | In Cyp2e1(-/-) mice pretreated with ethanol and isopentanol, subsequent exposure to 400 or 600 mg acetaminophen/kg resulted in centrilobular necrosis in all mice with maximal elevation in serum levels of ALT. | isopentyl alcohol | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 3 | Our findings that a 7-day treatment with ethanol and isopentanol causes extensive hepatic steatosis and increases acetaminophen hepatotoxicity in Cyp2e(-/-) mice indicate that CYP2E1 is not essential for either response. | isopentyl alcohol | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 4 | Our findings that a 7-day treatment with ethanol and isopentanol causes extensive hepatic steatosis and increases acetaminophen hepatotoxicity in Cyp2e(-/-) mice indicate that CYP2E1 is not essential for either response. | isopentyl alcohol | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |