Title : Structure of human transthyretin complexed with bromophenols: a new mode of binding.

Pub. Date : 2000 Sep

PMID : 10957627






6 Functional Relationships(s)
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1 The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography. 2,4,6-tribromophenol transthyretin Homo sapiens
2 The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography. 2,4,6-tribromophenol transthyretin Homo sapiens
3 The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography. 2,4,6-tribromophenol transthyretin Homo sapiens
4 The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography. 2,4,6-tribromophenol transthyretin Homo sapiens
5 The interactions with the halogens are smaller in number in TTR-TBP and there is a decrease in affinity, even though the interaction with the hydroxyl group is stronger than that in the TTR-PBP complex. 2,4,6-tribromophenol transthyretin Homo sapiens
6 The interactions with the halogens are smaller in number in TTR-TBP and there is a decrease in affinity, even though the interaction with the hydroxyl group is stronger than that in the TTR-PBP complex. 2,4,6-tribromophenol transthyretin Homo sapiens