Title : Interleukin-1beta regulates phospholipase D-1 expression in rat pancreatic beta-cells.

Pub. Date : 2000 Aug

PMID : 10919268






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PLD1 can induce phosphatidic acid formation and subsequent activation of protein kinase C, a process which stimulates insulin release. Phosphatidic Acids phospholipase D1 Rattus norvegicus
2 NG-methyl-L-arginine (LMA), a blocker of the inducible form of nitric oxide synthase (iNOS), prevented this late inhibitory effect of IL-1beta, suggesting that IL-1beta-induced decrease in PLD1a expression is NO-mediated. ng-methyl-l-arginine phospholipase D1 Rattus norvegicus
3 NG-methyl-L-arginine (LMA), a blocker of the inducible form of nitric oxide synthase (iNOS), prevented this late inhibitory effect of IL-1beta, suggesting that IL-1beta-induced decrease in PLD1a expression is NO-mediated. dodecyl methacrylate phospholipase D1 Rattus norvegicus