Title : Dual expression and differential regulation of phosphodiesterase 3A and phosphodiesterase 3B in human vascular smooth muscle: implications for phosphodiesterase 3 inhibition in human cardiovascular tissues.

Pub. Date : 2000 Aug

PMID : 10908291






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Although our data confirms the expression of PDE3A in human blood vessel smooth muscle cells (HASMCs), we identify a previously unrecognized role for PDE3B in cAMP hydrolysis in human cardiovascular tissues. Cyclic AMP phosphodiesterase 3B Homo sapiens
2 Specifically, although both PDE3A and PDE3B were expressed in HASMCs, their subcellular expression pattern and regulated expression by cAMP were distinct, with only expression of PDE3B being subject to cAMP-regulated expression. Cyclic AMP phosphodiesterase 3B Homo sapiens
3 Specifically, although both PDE3A and PDE3B were expressed in HASMCs, their subcellular expression pattern and regulated expression by cAMP were distinct, with only expression of PDE3B being subject to cAMP-regulated expression. Cyclic AMP phosphodiesterase 3B Homo sapiens